[Image characterization of Alzheimer's disease associated with the E280A-PS1 mutation. Case-control study: MRI findings]. / Caracterización imagenológica de la enfermedad de Alzheimer asociada a la mutación E280A-PS1. Estudio caso-control: hallazgos en la resonancia magnética.
Rev Neurol
; 29(1): 6-12, 1999.
Article
em Es
| MEDLINE
| ID: mdl-10528301
INTRODUCTION AND METHODS: In order to compare the magnetic resonance image characteristics of individuals belonging to pedigrees carrying the mutation E280A-PS1 associated to early onset Alzheimer disease, coming from Antioquia, Colombia, 78 individuals were studied. 47 of them were carriers of the mutation, 23 of those presented symptoms and 31 individuals being controls (non carriers of the mutation). RESULTS: In summary, significative differences were appreciated between symptomatic individuals and those asymptomatic. There was not significant difference between asymptomatic carriers and the controls. The presence of the perihippocampal fissure constituted a difference statistically significant between the symptomatic individuals and those carriers asymptomatic and between the symptomatic ones and the controls. The interuncal distance increased significantly was another difference between symptomatic and asymptomatic individuals and among symptomatic and control group. The lobar atrophy and the ventriculomegaly were found in symptomatic individuals and they correlate with the disorder graveness. There was not significance in the presence of infarcts and/or hippocampal hyperintensities. CONCLUSION: These results corroborate the statement that magnetic resonance image is very useful in the diagnosis and follow-up of individuals affected by early onset Alzheimer disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Mutação Puntual
/
Doença de Alzheimer
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Colombia
Idioma:
Es
Revista:
Rev Neurol
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Espanha