Synthesis and in vitro antiprotozoal activity of thiophene ring-containing quinones.
Chem Pharm Bull (Tokyo)
; 47(9): 1221-6, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10517004
A series of quinones (3a-i, 4-9, 11) and aromatic compounds (2a, 2d, 2g) containing the thiophene ring were tested in vitro against the trypomastigote form of Trypanosoma cruzi and the promastigote forms of Leishmania. The quinones 3a-i, 4, 5a, b, 6 and 9 having the thiophene ring fused to a quinone nucleus were the most active members of the series. The electron affinities of the benzo[b]thiophene-4,7-quinones 3, evaluated by their LUMO energies and halfwave potentials, are reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Tiofenos
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Japão