[Effect of catecholamines on splanchnic perfusion in sepsis]. / Efecto de las catecolaminas sobre la perfusión esplácnica en la sepsis.
Rev Med Chil
; 127(6): 719-27, 1999 Jun.
Article
em Es
| MEDLINE
| ID: mdl-10513083
Splanchnic ischemia is frequent in sepsis and septic shock and is related to impairment in intestinal permeability, derangement in mucosal barrier functions and translocation of proinflammatory mediators. These changes can contribute to the pathogenesis of multiple organ failure. Vasoactive drugs such as dobutamine and dopexamine can improve splanchnic perfusion and gastric intramucosal pH during sepsis. However, contradictory results have been obtained with dopamine and norepinephrine. On the other hand, epinephrine further impairs splanchnic perfusion. In view of the contradictory effects of different vasoactive drugs, gastric tonometry must be measured during their use, to find the optimal drug combination that optimizes splanchnic blood flow.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Circulação Esplâncnica
/
Vasoconstritores
/
Dopamina
/
Norepinefrina
/
Sepse
Limite:
Humans
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Chile