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Exogenous NGF alters a critical motor period in rat striatum.
Wolansky, M J; Cabrera, R J; Ibarra, G R; Mongiat, L; Azcurra, J M.
Afiliação
  • Wolansky MJ; Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Neuroreport ; 10(13): 2705-9, 1999 Sep 09.
Article em En | MEDLINE | ID: mdl-10511427
In previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces a bilateral lifetime drop in Bmax of the muscarinic radioligand [3H]QNB in striatum. We examined the possibility that striatal NGF level would be a determining factor for the normal occurrence of this synaptic plasticity. With this aim, rats underwent training at P30-37 with or without simultaneous NGF perfusion into the left striatum. At P70, we found the expected bilateral enduring fall of striatal [3H]QNB sites in trained controls. While the non-cannulated side of NGF-treated trained rats showed a similar drop in [3H]QNB binding, the perfused striata from these animals were not affected by training. Thus, the findings add new evidence in favour of a major role of NGF in this critical period of activity-dependent permanent adjustment in the striatal muscarinic system.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Corpo Estriado / Fator de Crescimento Neural / Animais Recém-Nascidos / Atividade Motora Limite: Animals Idioma: En Revista: Neuroreport Assunto da revista: NEUROLOGIA Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Corpo Estriado / Fator de Crescimento Neural / Animais Recém-Nascidos / Atividade Motora Limite: Animals Idioma: En Revista: Neuroreport Assunto da revista: NEUROLOGIA Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido