The biotransformation of ent-kaur-16-en-19-oic acid by Rhizopus stolonifer.

Silva, E A; Takahashi, J A; Boaventura, M A; Oliveira, A B

Silva, E A; Takahashi, J A; Boaventura, M A; Oliveira, A B.

Afiliação

Silva EA; Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Phytochemistry ; 52(3): 397-400, 1999 Oct.

Article em En | MEDLINE | ID: mdl-10501025

RESUMO

Microbial transformation of ent-kaur-16-en-19-oic acid was carried out with R. stolonifer. After seven days of incubation, two metabolites, ent-7 alpha-hydroxy-kaur-16-en-19-oic acid and ent-12 beta-hydroxy-kaur-9(11),16-dien-19-oic acid, were isolated as a result of hydroxylation and hydroxylation/dehydrogenation, respectively. Incubation for 15 days also afforded ent-16 beta,17-dihydroxy-kauran-19-oic acid. The metabolites were identified by spectroscopic methods.

Assuntos

Rhizopus/metabolismo; Biotransformação; Diterpenos/química; Diterpenos/farmacocinética; Estrutura Molecular; Análise Espectral

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rhizopus Idioma: En Revista: Phytochemistry Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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