Nitric oxide participates in the immune response against Neisseria meningitidis serogroup B.
FEMS Immunol Med Microbiol
; 25(4): 385-9, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10497870
The present report explores the role of nitric oxide into the immune response against Neisseria meningitidis serogroup B. Here we show that NO mediates the alphaTNF increase induced by N. meningitidis derived lipopolysaccharides (LPS), at the same time that participates in the bactericidal activity of resting or gammaIFN activated macrophages and plays a role in the specific DTH and IgG response induced by a commercial anti-meningococcal vaccine. Our findings suggest a positive role for NO at the final effector mechanisms and in the early events driving the immunity against N. meningitidis, suggesting also an insight into its role in endotoxic shock.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neisseria meningitidis
/
Óxido Nítrico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEMS Immunol Med Microbiol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Reino Unido