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Antiviral activity of enterocin CRL35 against herpesviruses.
Wachsman, M B; Farías, M E; Takeda, E; Sesma, F; de Ruiz Holgado, A P; de Torres, R A; Coto, C E.
Afiliação
  • Wachsman MB; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina. wachsman@qb.fcen.uba.ar
Int J Antimicrob Agents ; 12(4): 293-9, 1999 Aug.
Article em En | MEDLINE | ID: mdl-10493605
Enterocin CRL35 is an antibacterial polypeptide of 3.5 x 10(3) Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 microg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Bacteriocinas / Herpesvirus Humano 2 / Herpesvirus Humano 1 Limite: Animals Idioma: En Revista: Int J Antimicrob Agents Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda
Buscar no Google
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Bacteriocinas / Herpesvirus Humano 2 / Herpesvirus Humano 1 Limite: Animals Idioma: En Revista: Int J Antimicrob Agents Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda