Antiviral activity of enterocin CRL35 against herpesviruses.
Int J Antimicrob Agents
; 12(4): 293-9, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10493605
Enterocin CRL35 is an antibacterial polypeptide of 3.5 x 10(3) Da produced by Enterococcus faecium CRL35. A series of experiments are described that show the enterocin also had antiviral activity against thymidine-kinase positive (tk+) and deficient (tk-) strains of herpes simplex (HSV) type 1 and 2 in Vero and BHK-21 cells. This activity was observed at 100 microg/ml, 15-fold lower than the cytotoxic concentration. In both cell lines there was a 2 log inhibition of infectivity. The compound inhibited viral multiplication in a dose-dependent manner and had no virucidal effect. Enterocin CRL35 also inhibited the virion-associated host shutoff in infected Vero cells showing that intracellular viral multiplication was affected.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Bacteriocinas
/
Herpesvirus Humano 2
/
Herpesvirus Humano 1
Limite:
Animals
Idioma:
En
Revista:
Int J Antimicrob Agents
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Holanda