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Early changes in nitric oxide synthase activity in atrial intramural arteries following experimental spinal cord injury in rats.
Bravo, G; Larios, F; Rojas-Martínez, R; Hong, E; Salazar, L A; Guízar-Sahagún, G.
Afiliação
  • Bravo G; Depto. Farmacología y Toxixología, México D.F., Mexico. gbravof@dfl.telmex.net.mx
Neurosci Lett ; 271(1): 37-40, 1999 Aug 13.
Article em En | MEDLINE | ID: mdl-10471208
Previously, we have shown that immediately after an experimental spinal cord injury (SCI) in anaesthetized rats, there is a large fall in mean arterial pressure (MAP) and heart rate (HR), followed by an abrupt increase in MAP. To evaluate the participation of nitric oxide (NO), we evaluated the activity of nitric oxide synthase (NOS) using Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry in sections of atria at several post-injury time-intervals. Staining increased at 3 min, reached a maximum at 9 min and diminished 30 min after injury. Pretreatment with atropine prevented changes in MAP, HR and NADPH-d staining suggesting that such modifications result from an increased vagal stimulation. In conclusion, the NOS activity is transiently elevated in the atrial intramural arteries of rats subjected to an SCI.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Óxido Nítrico Sintase / Vasos Coronários Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 1999 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Óxido Nítrico Sintase / Vasos Coronários Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 1999 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda