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Clinical forms of human Schistosoma mansoni infection are associated with differential activation of T-cell subsets and costimulatory molecules.
Martins-Filho, O A; Cunha-Melo, J R; Lambertucci, J R; Silveira, A M; Colley, D G; Gazzinelli, G; Correa-Oliveira, R.
Afiliação
  • Martins-Filho OA; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil.
Dig Dis Sci ; 44(3): 570-7, 1999 Mar.
Article em En | MEDLINE | ID: mdl-10080152
The current study has compared the activation status and the expression of the CD28 molecule on circulating CD4+ and CD8+ lymphocytes from patients with different clinical forms of schistosomiasis. The data show that patients with acute schistosomiasis have an increase on the mean percentage of CD4+ HLA-DR+ cells, whereas chronic asymptomatic patients exhibit an increased mean percentage of CD8+ HLA-DR+ cells. Patients with the hepatosplenic disease showed an increase in both CD4+ HLA-DR+ and CD8+ HLA-DR+ cells. Despite the high levels of CD8+ HLA-DR+ cells in hepatosplenic patients, they presented a decreased ratio of CD8+ CD28+/CD8+ cells. These findings of a different percentage of circulating CD8+ CD28+ cells might explain the different in vitro cellular reactivity of asymptomatic and hepatosplenic patients and the defects in the cytokine secretion patterns reported in individuals with hepatosplenic schistosomiasis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Ativação Linfocitária / Subpopulações de Linfócitos T / Antígenos CD28 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Humans / Middle aged Idioma: En Revista: Dig Dis Sci Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Ativação Linfocitária / Subpopulações de Linfócitos T / Antígenos CD28 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Humans / Middle aged Idioma: En Revista: Dig Dis Sci Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos