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Impact of tuberculosis on the body composition of HIV-infected men in Brazil.
Paton, N I; Castello-Branco, L R; Jennings, G; Ortigao-de-Sampaio, M B; Elia, M; Costa, S; Griffin, G E.
Afiliação
  • Paton NI; St. George's Hospital Medical School, Tooting, London, UK. Paton_NIJ@notes.ttsh.gov.sg
J Acquir Immune Defic Syndr Hum Retrovirol ; 20(3): 265-71, 1999 Mar 01.
Article em En | MEDLINE | ID: mdl-10077175
ABSTRACT
PIP: This paper examines the impact of tuberculosis (TB) on the body composition of HIV-positive men with treatment for active TB (HIV/TB+) and HIV-infected men without TB (HIV/TB-) in Brazil. Total body water (TBW) and extracellular water (ECW) were measured by giving oral doses of deuterium oxide and sodium bromide, respectively, and determining the enrichment in plasma after 4 hours. Calculated from these parameters are the intracellular water (ICW), body cell mass (BCM), lean body mass (LBM) and fat mass. Age, height, CD4 count and HIV risk factors were similar among HIV/TB+ (n = 11) and HIV/TB- (n = 12). HIV/TB+ patients had significantly lower mean ICW (13.2 vs. 16.6 kg) and BCM (18.4 vs. 23 kg), a relative expansion of ECW (35 vs. 30 l/kg body weight, nonsignificant reductions in TBW (58 vs. 62.1 kg), LBM (45.5 vs. 47.7 kg) and fat mass (12.5 vs. 14.4 kg) compared with HIV/TB- men. Nutritional status was found to be significantly worse among HIV+ patients. Malnutrition was also severe in HIV/TB+ patients, which contributed to a decreased life span. Hypermetabolism appears to play a role in the wasting process of patients with HIV and TB. To improve physical function, quality of life, and survival among HIV-infected patients with TB, optimization of nutritional status should be at the core of treatment.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Composição Corporal / Infecções Oportunistas Relacionadas com a AIDS Tipo de estudo: Risk_factors_studies Aspecto: Patient_preference Limite: Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Acquir Immune Defic Syndr Hum Retrovirol Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) / VIROLOGIA Ano de publicação: 1999 Tipo de documento: Article País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Composição Corporal / Infecções Oportunistas Relacionadas com a AIDS Tipo de estudo: Risk_factors_studies Aspecto: Patient_preference Limite: Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Acquir Immune Defic Syndr Hum Retrovirol Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) / VIROLOGIA Ano de publicação: 1999 Tipo de documento: Article País de publicação: Estados Unidos