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Nerve growth factor preserves a critical motor period in rat striatum.
Wolansky, M J; Paratcha, G C; Ibarra, G R; Azcurra, J M.
Afiliação
  • Wolansky MJ; Proyecto IPON, Cátedra de Biología Celular, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Universidad de Buenos Aires, Argentina.
J Neurobiol ; 38(1): 129-36, 1999 Jan.
Article em En | MEDLINE | ID: mdl-10027568
We previously found the occurrence of a critical motor period during rat postnatal development where circling training starting the 7-day schedule at 30 days-but not before or after-induces a lifetime drop in the binding to cholinergic muscarinic receptors (mAChRs) in striatum. Here, we studied whether nerve growth factor (NGF) participates in this restricted period of muscarinic sensitivity. For this purpose, we administered mouse salival gland 2.5S NGF (1.4 or 0.4 microg/day, infused by means of ALZA minipumps) by intrastriatal unilateral route between days 25 and 39, and then trained rats starting at 40 days. Under these conditions, NGF induced a long-term reduction in the striatal [3H] quinuclidilbenzylate (QNB) binding sites despite the fact that motor training was carried out beyond the natural critical period. Thus, at day 70, measurement of specific QNB binding in infused striata of trained rats showed decreases of 42% (p < .0004) and 33% (p < .02) after administration of the higher and lower NGF doses, respectively, with respect to trained rats treated with cytochrome C, for control. Noncannulated striata of the NGF-treated rats also showed a decrease in QNB binding sites (44%; p < .0001) only at the higher infusion rate. This effect was not found in the respective control groups. Our observations show that NGF modulates the critical period in which activity-dependent mAChR setting takes place during rat striatal maturation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Receptores Muscarínicos / Atividade Motora / Fatores de Crescimento Neural Limite: Animals Idioma: En Revista: J Neurobiol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Receptores Muscarínicos / Atividade Motora / Fatores de Crescimento Neural Limite: Animals Idioma: En Revista: J Neurobiol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos