Carbamazepina: biodisponibilidad de cuatro productos farmacéuticos orales / Bioavailability of carbamazepine from 4 products
Rev. méd. Chile
; 118(10): 1123-8, oct. 1990. tab
Article
em Es
| LILACS
| ID: lil-96808
Biblioteca responsável:
CL1.1
ABSTRACT
The bioavailability of carba,azepine from 4 comercially available products was evaluated in 12 healthy volonteers. A crossover design was used and each patients received 400 mg of each product. Plasma levels of the drug were determined periodically for 72 h using a gas-liquid chromatographic method. An open model of one compartment for first-order absortion was assumed to derive pharmacokinetic parameters. Dissolution kinetics was also evaluated in each product. Significant differences in biovailability were shown for one product. Results correlated with the in vitro dissolution findings:
Buscar no Google
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Carbamazepina
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Project document
País de publicação:
Chile