Etiopatogenia de la úlcera aguda por estres: rol de los oxidantes derivados del oxígeno / Pathogenesis of gastric stress ulcer: role of oxygen free radicals
Rev. méd. Chile
; 118(9): 965-70, sept. 1990. ilus
Article
em Es
| LILACS
| ID: lil-96532
Biblioteca responsável:
CL1.1
ABSTRACT
We evaluated the role of oxygen free radicals in the induction of acute stress gastric ulcer in rats. After 12 hr of inmobility, ulcers of up to 4 mm were observed in the gastric mucosa. Pretreatment with allopurinol, a xantine oxydase inhibitor, produced a significant reduction in the number and size of lesions (p < 0.0001). No protection was afforded by aluminum hydroxyde or ranitidine alone, but enhanced protection was observed when given in association to allopurinol. A secondary role for H ions is suggested by these findings. Our results support the hypothesis of a role of a oxygen free radicals in the pathogenesis of stress gastric ulcers. Allopurinol might be used in conditions prodisposing to stress in patients
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Úlcera Péptica
/
Estresse Fisiológico
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Project document
País de publicação:
Chile