Interaction between cholinergic and opiate receptors of the lateral hypothalamus in the control of renal excretion in rats
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;23(6/7): 613-6, 1990. ilus
Article
em En
| LILACS
| ID: lil-92458
Biblioteca responsável:
BR26.1
ABSTRACT
The present study was carried out to investigate the participation and interaction between cholinergic and opiate receptors of the lateral hypothalamus (LH) in the regulation of Na+, K+ and water excretion. Malew Holtzman rats were implanted with chronic cerebral cannulas into the LH. Urine was collected over a period of 2h after injection of carbachol, FK-33824 + carbachol or naloxone + carbachol into the LH. Carbachol (8nmol) reduced urinary volume and increased Na + excretion. Previous injection of FK-333824(100ng) into the LH increased the antidiuretic effect of carbachol, but blocked the increase in Na+ excretion and decreased K+ excretion. Naloxone. Naloxone (10microng) produced no changes in the effect of carbacho9l on renal excretion. These data show an inhibitory effect of opiate receptors on the changes in urinary Na+ and K+ excretion that are induced by chronergic stimulation of the LH in rats, and a potentiating effect on antidiuresis
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Carbacol
/
Receptores Colinérgicos
/
Receptores Opioides
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Congress and conference
País de publicação:
Brasil