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Interaction between cholinergic and opiate receptors of the lateral hypothalamus in the control of renal excretion in rats
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;23(6/7): 613-6, 1990. ilus
Article em En | LILACS | ID: lil-92458
Biblioteca responsável: BR26.1
ABSTRACT
The present study was carried out to investigate the participation and interaction between cholinergic and opiate receptors of the lateral hypothalamus (LH) in the regulation of Na+, K+ and water excretion. Malew Holtzman rats were implanted with chronic cerebral cannulas into the LH. Urine was collected over a period of 2h after injection of carbachol, FK-33824 + carbachol or naloxone + carbachol into the LH. Carbachol (8nmol) reduced urinary volume and increased Na + excretion. Previous injection of FK-333824(100ng) into the LH increased the antidiuretic effect of carbachol, but blocked the increase in Na+ excretion and decreased K+ excretion. Naloxone. Naloxone (10microng) produced no changes in the effect of carbacho9l on renal excretion. These data show an inhibitory effect of opiate receptors on the changes in urinary Na+ and K+ excretion that are induced by chronergic stimulation of the LH in rats, and a potentiating effect on antidiuresis
Assuntos
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Carbacol / Receptores Colinérgicos / Receptores Opioides / Hipotálamo Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1990 Tipo de documento: Article / Congress and conference País de publicação: Brasil
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Carbacol / Receptores Colinérgicos / Receptores Opioides / Hipotálamo Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1990 Tipo de documento: Article / Congress and conference País de publicação: Brasil