Mechanism of potassium transport across proximal tubule epithelium in the rat
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;23(11): 1195-9, 1990. tab, ilus
Article
em En
| LILACS
| ID: lil-91626
Biblioteca responsável:
BR26.1
ABSTRACT
The mechanism of proximal tubule potassium reabsorption was studied by stopped-flow microperfusion and determination of potassium activities by ion-sensitive resin microelectrodes. The proximal tubule was unable to establish transepithelial potassium gradients. perfusion with 20 mM K+ turned the lumen 3 mV more negative, an effect abolished by Ba2+. the half-time for K+ activities to reach their stationary level after perfusion with 1 mMK+ was significantly increased by Ba2+ from 4.25 ñ 0.14sto 11.0 ñ 1.71s, and aftr perfusion with 20 mMK+, from 5.43 ñ 0.20 to 12.53 ñ 0.90s. These data indicate that a significant fraction of potassium is transferred across proximal tubule spithelium by a transcellular, K+-channel-dependent route
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Potássio
/
Túbulos Renais Proximais
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Congress and conference
País de publicação:
Brasil