Desipramine blocks stress-induced prolactin release in rats: role of central beta-2 adrenoceptors
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;23(2): 199-204, 1990. ilus
Article
em En
| LILACS
| ID: lil-85159
Biblioteca responsável:
BR26.1
ABSTRACT
The present study was designed to examine the relationship between beta-adrenoceptors and the enhanced, sustained prolactin secretion induced by immobilization stress in rats. Chronic administration of desipramine (15 mg kg**-1 day**-1, intraperitoneally) for 7 days, a procedure that desensitizes central beta-adrenoceptors, partially inhibits stress-induced prolactin release. Intracerebroventricular adminsitration of the beta-2 adrenoceptor agonist salbutamol (1 microng/rat) to rats pretreated with desipramine for 7 days, 15 min before immobilization, significantly relieved the inhibition by desipramine 5 and 10 min after the initiation of stress but the effect was not demonstrable after 20 and 40 min. We conclude that beta-2 adrenoceptors play a role in the control prolactin release in response to stress
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Prolactina
/
Estresse Fisiológico
/
Desipramina
/
Albuterol
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Project document
País de publicação:
Brasil