Substance P and naloxone enhancement of avoidance conditioning in rats
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;23(2): 163-7, 1990. tab
Article
em En
| LILACS
| ID: lil-85153
Biblioteca responsável:
BR26.1
ABSTRACT
Experiments were carried out to investigate the effects of peripheral post-training administration of substance P (SP) and naloxone on learning. Rats were trained in three different avoidance tasks (uphill, step-down and alcove) and tested 24 h later. Thirty minutes before each trial (training and testing) rats received naloxone (0.5, 1, 5, or 50 mg/kg, ip) or saline. SP (50 microng/kg) or vehicle was administered ip immediately after training. Animals that received SP and SP in combination with naloxone (5 and 50 mg/kg) showed significantly better retention test performance for the uphill and step-down avoidance (P < 0.05 when compared to control rats treated with vehicle). In the alcove task no influence of SP and/or naloxone was demonstrable, probably due to a ceiling effect. These results suggest that the memory enhancement effects observed are mediated, at least in part, via interactions between substance P and the endogenous opioid systems
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Retenção Psicológica
/
Aprendizagem da Esquiva
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Substância P
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Condicionamento Psicológico
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Naloxona
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Project document
País de publicação:
Brasil