Effects of thymoquinone against cisplatin-induced cardiac injury in rats
Acta cir. bras
; Acta cir. bras;31(4): 271-277, Apr. 2016. tab, graf
Article
em En
| LILACS
| ID: lil-781332
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury.METHODS:
A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days).RESULTS:
There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups.CONCLUSION:
Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Benzoquinonas
/
Cisplatino
/
Cardiomiopatias
/
Antineoplásicos
/
Antioxidantes
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Brasil