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Familial Mediterranean Fever is associated with abnormal ventricular repolarization indices / La fiebre mediterránea familiar se asocia a anomalías en la repolarizacıón ventricular
Ahbap, Elbis; Sakaci, Tamer; Kara, Ekrem; Sahutoglu, Tuncay; Ozturk, Semi; Basturk, Taner; Koc, Yener; Sevinc, Mustafa; Akgol, Cuneyt; Ucar, Zuhal Atan; Kayalar, Arzu Ozdemir; Caglayan, Feyza Bayraktar; Gurbuz, Seyfettin; Unsal, Abdulkadir.
Afiliação
  • Ahbap, Elbis; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Sakaci, Tamer; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Kara, Ekrem; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Sahutoglu, Tuncay; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Ozturk, Semi; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Basturk, Taner; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Koc, Yener; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Sevinc, Mustafa; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Akgol, Cuneyt; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Ucar, Zuhal Atan; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Kayalar, Arzu Ozdemir; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Caglayan, Feyza Bayraktar; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Gurbuz, Seyfettin; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
  • Unsal, Abdulkadir; Sisli Hamidiye Etfal Educational and Research Hospital. Department of Nephrology. Istanbul. TR
Rev. méd. Chile ; 143(12): 1560-1568, dic. 2015. graf, tab
Article em En | LILACS | ID: lil-774442
Biblioteca responsável: CL1.1
ABSTRACT

Background:

Cardiac arrhythmias can be a part of cardiovascular involvement in some rheumatic diseases, but data about familial Mediterranean fever (FMF) are conflicting.

Aim:

To search for abnormalities in ventricular repolarization indices in FMF patients. Patients and

Methods:

Seventy seven FMF patients and 30 age/gender comparable healthy controls were included. All patients were attack free and subjects with disease or drugs that are known to alter cardiac electrophysiology were excluded. Electrocardiographic data were obtained and analyzed.

Results:

Twelve FMF patients had amyloidosis. QT and QTc intervals were within the normal ranges and similar between FMF patients and healthy controls. QT dispersion, peak to end interval of T wave (Tpe), Tpe/QT and Tpe/QTc ratios were significantly higher in FMF patients than in healthy controls. Patients with amyloidosis had significantly higher QT dispersion, Tpe, Tpe/QT and Tpe/QTc than their counterparts without FMF. Levels of proteinuria were moderately correlated with QT dispersion, Tpe, Tpe/QT and Tpe/QTc.

Conclusions:

FMF patients may have an increased risk for arrhythmias.
RESUMEN
Antecedentes Las arritmias cardíacas pueden ser parte del compromiso cardíaco en enfermedades reumáticas, sin embargo, no se sabe con certeza si esto ocurre en la fiebre mediterránea familiar (FMF).

Objetivo:

Buscar anomalías en la repolarización ventricular en pacientes con FMF. Pacientes y

Métodos:

Sesenta y siete pacientes como FMF y 30 controles sanos pareados por edad y género fueron estudiados. Todos los pacientes estaban en período intercrítico y no usaban medicamentos o tenían enfermedades concomitantes que pudieran causar anomalías electrocardiográficas. Se analizaron los electrocardiogramas de estos participantes.

Resultados:

Veinte pacientes con FMF tenían amiloidosis. Los intervalos QT y QTc eran normales y similares entre pacientes y controles. La dispersión del intervalo QT, el intervalo desde el peak al final de la onda T (Tpe), las razones Tpe/QT y Tpe/QTc fueron significativamente más altos en los pacientes que en los controles. Los pacientes con amiloidosis tenían una dispersión de QT, Tpe, Tpe/QT y Tpe/QTc mayores que sus pares sin la condición. Los niveles de proteinuria se correlacionaron moderadamente con los parámetros antes mencionados.

Conclusiones:

Los pacientes con FMF tienen mayor riesgo de arritmias.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Febre Familiar do Mediterrâneo / Arritmias Cardíacas / Amiloidose Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Chile

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Febre Familiar do Mediterrâneo / Arritmias Cardíacas / Amiloidose Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Chile