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Could CD64 expression be used as a predictor of positive culture results in children with febrile neutropenia?
Barbosa, Gustavo Gõhringer de Almeida; Farias, Mariela Granero; Ludwig, Helena Cocolichio; Stensmann, Isabel; Fernandes, Matheus Vanzin; Michalowski, Mariana Bohns; Daudt, Liane Esteves.
Afiliação
  • Barbosa, Gustavo Gõhringer de Almeida; Universidade Federal do Rio Grande do Sul. Porto Alegre. BR
  • Farias, Mariela Granero; Universidade Federal do Rio Grande do Sul. Porto Alegre. BR
  • Ludwig, Helena Cocolichio; Pontifícia Universidade Católica de Rio Grande do Sul. Porto Alegre. BR
  • Stensmann, Isabel; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Fernandes, Matheus Vanzin; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Michalowski, Mariana Bohns; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Daudt, Liane Esteves; Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre. BR
Rev. bras. hematol. hemoter ; Rev. bras. hematol. hemoter;37(6): 395-399, Oct.-Dec. 2015. tab
Article em En | LILACS | ID: lil-769976
Biblioteca responsável: BR408.1
ABSTRACT

Background:

Early recognition of infectious processes in neutropenic patients is hampered by the fact that these processes may have dissimilar and non-specific clinical presentations. CD64 is a neutrophil surface marker that is not expressed in non-sensitized neutrophils. When the neutrophil is exposed to tumor necrosis factor-alpha it is activated and is measured via the CD64 index.

Methods:

This paper evaluated the relationship between the index value of CD64 on the first day of febrile neutropenia and a positive blood culture. The correlations with white blood count, C-reactive protein and erythrocyte sedimentation rate were also evaluated. This case-control, prospective, diagnostic study included 64 episodes of neutropenia. Case group (n = 14) comprised positive blood cultures, and the control group (n = 50), negative blood cultures.

Results:

The median rates of CD64 were 2.1 (a ± 3.9) in the case group and 1.76 (a ± 5.02) in the control group. There was no correlation between the value of the CD64 index and blood cultures. The CD64 index was also not correlated with C-reactive protein positivity. Further- more, the CD64 index was not able to predict blood culture positivity. The sensitivity was 64.3%, the specificity was 42%, the positive predictive value was 23.7% and the negative predictive value was 80%. For C-reactive protein, the sensitivity, specificity, positive predictive value, and negative predictive value were 71.4%, 32%, 22.7%, and 80%, respectively.

Conclusion:

The CD64 index is not suitable for predicting the positivity of blood cultures in this specific population of patients with febrile neutropenia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteína C-Reativa / Receptores de IgG / Sepse / Neutropenia Febril / Citometria de Fluxo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Humans Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteína C-Reativa / Receptores de IgG / Sepse / Neutropenia Febril / Citometria de Fluxo Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Humans Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil