Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;48(9): 852-862, Sept. 2015. tab, ilus
Article
em En
| LILACS
| ID: lil-756406
Biblioteca responsável:
BR1.1
ABSTRACT
The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Dano ao DNA
/
Extratos Vegetais
/
Estresse Oxidativo
/
Ericales
/
Neoplasias Pulmonares
/
Antioxidantes
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2015
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
País de publicação:
Brasil