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Prostate-Specific Antigen fluctuation: what does it mean in diagnosis of prostate cancer?
Kim, Jun Seok; Ryu, Je-Guk; Kim, Jin Woong; Hwang, Eu Chang; Jung, Seung Il; Kang, Taek Won; Kwon, Dongdeuk; Park, Kwangsung.
Afiliação
  • Kim, Jun Seok; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Ryu, Je-Guk; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Kim, Jin Woong; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Hwang, Eu Chang; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Jung, Seung Il; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Kang, Taek Won; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Kwon, Dongdeuk; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
  • Park, Kwangsung; Kwangju Christian Hospital. Department of Urology. Gwangju. KR
Int. braz. j. urol ; 41(2): 258-264, Mar-Apr/2015. tab, graf
Article em En | LILACS | ID: lil-748296
Biblioteca responsável: BR1.1
ABSTRACT
Objective To investigate whether prostate-specific antigen (PSA) fluctuation correlates with a prostate cancer and to assess whether PSA fluctuation could be used for diagnosis of prostate cancer. Materials and Methods Our study included 229 patients who were performed a prostate biopsy (non-cancer group, 177; prostate cancer group, 52). Enrolled patients were provided twice PSA tests within 6 months. PSA fluctuation (%/month) was defined as a change rate of PSA per a month. Independent t test was used to compare between two groups. Receiver operator characteristic curve was used to assess the availability as a differential diagnostic tool and the correlation. Simple linear regression was performed to analyze a correlation between PSA fluctuation and other factors such as age, PSA, PSA density, and prostate volume. Results There were significant differences in PSA, PSA density, percentage of free PSA, and PSA fluctuation between two groups. PSA fluctuation was significantly greater in non-cancer group than prostate cancer group (19.95±23.34%/month vs 9.63±8.57%/month, P=0.004). The most optimal cut-off value of PSA fluctuation was defined as 8.48%/month (sensitivity, 61.6%; specificity, 59.6%; AUC, 0.633; P=0.004). In a simple linear regression model, only PSA level was significantly correlated with PSA fluctuation. Conclusion Patients with wide PSA fluctuations, although baseline PSA levels are high, might have a low risk of diagnosis with prostate cancer. Thus, serial PSA measurements could be an option in patients with an elevated PSA level. .
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Modelos Estatísticos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article / Project document País de afiliação: Coréia do Sul País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Modelos Estatísticos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article / Project document País de afiliação: Coréia do Sul País de publicação: Brasil