Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia
Acta cir. bras
; Acta cir. bras;29(12): 807-811, 12/2014. tab, graf
Article
em En
| LILACS
| ID: lil-731022
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QTc interval.METHODS:
This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups sugammadex group (Group S, n5) and neostigmine group (Group N, n5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2, 5, 10, 20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex.RESULTS:
Comparing the QTc interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QTc interval in the neostigmine group rabbits was significantly increased (p<0.05).CONCLUSION:
While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QTc interval, neostigmine+atropine proloned the QTc interval. .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Inibidores da Colinesterase
/
Gama-Ciclodextrinas
/
Coração
/
Anestesia Geral
/
Neostigmina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Article
/
Project document
País de afiliação:
Turquia
País de publicação:
Brasil