Genética, HLA-B27 y espondilitis anquilosante: 40 años / Genetics of ankylosing spondylitis
Rev. méd. Chile
; 142(9): 1165-1173, set. 2014. ilus, tab
Article
em Es
| LILACS
| ID: lil-730288
Biblioteca responsável:
CL1.1
ABSTRACT
Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients quality of life.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Espondilite Anquilosante
/
Predisposição Genética para Doença
Aspecto:
Patient_preference
Limite:
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile