Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Acta cir. bras
; Acta cir. bras;29(10): 667-674, 10/2014. tab, graf
Article
em En
| LILACS
| ID: lil-725291
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate E-cadherin immunoexpression during cervical carcinogenesis.METHODS:
We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis.RESULTS:
The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis.CONCLUSIONS:
E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Carcinoma de Células Escamosas
/
Caderinas
/
Cervicite Uterina
/
Neoplasias do Colo do Útero
/
Lesões Intraepiteliais Escamosas Cervicais
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil