Microambiente medular en la leucemia mieloide crónica: su relación con la enfermedad y la respuesta al tratamiento / Bone marrow microenvironment in chronic myeloid leukemia: Implications for disease physiopathology and response to treatment
Rev. méd. Chile
; 142(5): 599-605, mayo 2014. ilus, tab
Article
em Es
| LILACS
| ID: lil-720669
Biblioteca responsável:
CL1.1
ABSTRACT
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm related to the presence of the BCR-ABL1 fusion gene, linked to t (9;22) (q34;q11). It is originated from an abnormal hematopoietic stem cell, which is characterized as its normal counterparts by long-term self-renewal and multi-lineage differentiation. Both leukemic and quiescent normal hematopoietic stem cells preferentially reside in the osteoblastic niche. Mesenchymal stromal cells (MSC) are located near them, playing a critical role in their regulation. Currently, with tyrosine kinase inhibitor (TKI) therapy, long term clinical responses are achieved in most CML cases. However, late treatment failures may be observed related to the persistence of leukemic stem cells. The interactions between the leukemic stem cell and the microenvironment may be responsible in part for these events. We review the interactions between the leukemic stem cell and BM stroma and its potential clinical and therapeutic implications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Medula Óssea
/
Células-Tronco Hematopoéticas
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Resistencia a Medicamentos Antineoplásicos
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Células-Tronco Mesenquimais
Limite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Chile