Your browser doesn't support javascript.
loading
Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure
Wang, Y.; Mu, J.J.; Liu, F.Q.; Ren, K.Y.; Xiao, H.Y.; Yang, Z.; Yuan, Z.Y..
Afiliação
  • Wang, Y.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Mu, J.J.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Liu, F.Q.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Ren, K.Y.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Xiao, H.Y.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Yang, Z.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
  • Yuan, Z.Y.; Xi'an Jiaotong University. Medical College. First Affiliated Hospital. Cardiovascular Department. Xi'an. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;47(3): 223-230, 03/2014. tab, graf
Article em En | LILACS | ID: lil-704622
Biblioteca responsável: BR1.1
ABSTRACT
Dietary salt intake has been linked to hypertension and cardiovascular disease. Accumulating evidence has indicated that salt-sensitive individuals on high salt intake are more likely to develop renal fibrosis. Epithelial-to-mesenchymal transition (EMT) participates in the development and progression of renal fibrosis in humans and animals. The objective of this study was to investigate the impact of a high-salt diet on EMT in Dahl salt-sensitive (SS) rats. Twenty-four male SS and consomic SS-13BN rats were randomized to a normal diet or a high-salt diet. After 4 weeks, systolic blood pressure (SBP) and albuminuria were analyzed, and renal fibrosis was histopathologically evaluated. Tubular EMT was evaluated using immunohistochemistry and real-time PCR with E-cadherin and alpha smooth muscle actin (α-SMA). After 4 weeks, SBP and albuminuria were significantly increased in the SS high-salt group compared with the normal diet group. Dietary salt intake induced renal fibrosis and tubular EMT as identified by reduced expression of E-cadherin and enhanced expression of α-SMA in SS rats. Both blood pressure and renal interstitial fibrosis were negatively correlated with E-cadherin but positively correlated with α-SMA. Salt intake induced tubular EMT and renal injury in SS rats, and this relationship might depend on the increase in blood pressure.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Pressão Sanguínea / Cloreto de Sódio na Dieta / Ratos Endogâmicos Dahl / Transição Epitelial-Mesenquimal / Rim Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Pressão Sanguínea / Cloreto de Sódio na Dieta / Ratos Endogâmicos Dahl / Transição Epitelial-Mesenquimal / Rim Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil