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Tuberculin skin testing in inflammatory bowel disease patients from an endemic area of Brazil
Cardoso, Ingrid Puig; de Almeida, Neogelia Pereira; Gotardo, Daniela Rosa; Cardeal, Mauricio; Santana, Genoile Oliveira.
Afiliação
  • Cardoso, Ingrid Puig; Roberto Santos General Hospital. Gastroenterology Unit. Salvador. BR
  • de Almeida, Neogelia Pereira; Roberto Santos General Hospital. Gastroenterology Unit. Salvador. BR
  • Gotardo, Daniela Rosa; Roberto Santos General Hospital. Gastroenterology Unit. Salvador. BR
  • Cardeal, Mauricio; Roberto Santos General Hospital. Gastroenterology Unit. Salvador. BR
  • Santana, Genoile Oliveira; Roberto Santos General Hospital. Gastroenterology Unit. Salvador. BR
Braz. j. infect. dis ; Braz. j. infect. dis;18(1): 60-64, Jan-Feb/2014. tab
Article em En | LILACS | ID: lil-703052
Biblioteca responsável: BR1.1
ABSTRACT

Objective:

Inflammatory bowel disease (IBD) is a chronic disorder involving the gastrointestinal tract. Immunosuppressive drugs are usually prescribed to treat IBD patients, and this treatment can lead to tuberculosis reactivation. This paper aimed to analyze tuberculin skin test (TST) results in IBD patients at a reference center in Brazil.

Methods:

We evaluated TST results in IBD patients using a cross-sectional study. We also analyzed the medical records of patients treated at a reference IBD outpatient unit where TST is routinely performed.

Results:

We reviewed 119 medical records of 57 (47.9%) Crohn's disease (CD), 57 (47.9%) ulcerative colitis (UC) and 5 (4.2%) indeterminate colitis (IC) patients. The mean (SD) age was 43.5 (13.7) years old. TST was positive in 24 (20.2%) of the patients. TST was positive in 16/57 (28.1%) UC and 6/57 (10.5%) CD patients (prevalence ratio [PR] 2.7). Forty-one patients (34.5%) were taking immunosuppressive drugs (azathioprine or prednisone) at the time of the TST, and six of these patients (14.6%) had positive test results. Two patients using infliximab had negative TST results. Thirty-five of the 41 patients (85.4%) on immunosuppressive treatment were anergic compared with 73.1% (57/78) of the untreated patients (PR 1.2).

Conclusions:

Patients with IBD have TST results similar to the general Brazilian population. Within the IBD population, CD patients have a lower frequency of TST positivity than UC patients. .
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tuberculose / Teste Tuberculínico / Doenças Inflamatórias Intestinais / Doenças Endêmicas Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tuberculose / Teste Tuberculínico / Doenças Inflamatórias Intestinais / Doenças Endêmicas Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil