Identification of clinical, epidemiological and laboratory risk factors for leprosy reactions during and after multidrug therapy
Mem. Inst. Oswaldo Cruz
; 108(7): 901-908, 1jan. 2013. tab
Article
em En
| LILACS
| ID: lil-696016
Biblioteca responsável:
BR1.1
ABSTRACT
This cross-sectional retrospective study evaluated 440 leprosy patients; 57% (251/440) had leprosy reactions during and/or after multidrug therapy, 80.5% (202/251) of whom presented with multibacillary leprosy. At diagnosis, positive bacterial index (BI) [odds ratio (OR) = 6.39; 95% confidence interval (CI) 4.1-10.1)] or polymerase chain reaction (PCR) (OR = 9.15; 95% CI 5.4-15.5) in skin smears, anti-phenolic glycolipid-1 (anti-PGL-1) ELISA (OR = 4.77; 95% CI 2.9-7.9), leucocytosis (OR = 9.97; 95% CI 3.9-25.7), thrombocytopenia (OR = 5.72; 95% CI 2.3-14.0) and elevated lactate dehydrogenase (OR = 2.38; 95% CI 1.4-4.0) were potential markers for the development of reactions during treatment. After treatment, positive BI (OR = 8.47; 95% CI 4.7-15.3) and PCR (OR = 6.46; 95% CI 3.4-12.3) in skin smears, anti-PGL-1 ELISA (OR = 2.25; 95% CI 1.3-3.9), anaemia (OR = 2.36; 95% CI 1.2-4.5), leucocytosis (OR = 4.14; 95% CI 1.5-11.6) and thrombocytopenia (OR = 3.70; 95% CI 1.3-2.2) were risk factors for the occurrence of reactions during the study period. The identification of groups with an increased risk for developing reactions will allow for the timely development of a treatment plan to prevent nerve damage and, therefore, the appearance of the disabling sequelae associated with the stigma of leprosy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Hansenostáticos
/
Hanseníase
/
Anticorpos Antibacterianos
/
Mycobacterium leprae
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil