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The utility of lactate dehydrogenase in the follow up of patients with diffuse large B-cell lymphoma
William, Basem Magdy; Bongu, Navneeth Rao; Bast, Martin; Bociek, Robert Gregory; Bierman, Philip Jay; Vose, Julie Marie; Armitage, James Olen.
Afiliação
  • William, Basem Magdy; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Bongu, Navneeth Rao; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Bast, Martin; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Bociek, Robert Gregory; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Bierman, Philip Jay; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Vose, Julie Marie; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
  • Armitage, James Olen; Case Western Reserve University. University Hospitals Case Medical Center. Cleveland. US
Rev. bras. hematol. hemoter ; Rev. bras. hematol. hemoter;35(3): 189-191, jun. 2013. tab
Article em En | LILACS | ID: lil-681974
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT

Background:

Serum lactate dehydrogenase is a non-specific marker for lymphoma whose prognostic significance is well established for both indolent and aggressive lymphomas at the time of diagnosis. The performance characteristics of this enzyme in predicting relapse in patients with diffuse large B-cell lymphoma has not been well studied.

Methods:

This study compared serum lactate dehydrogenase levels in 27 patients with diffuse large B-cell lymphoma who relapsed after sustaining a complete response versus 87 patients who did not relapse. For relapsed patients, the serum lactate dehydrogenase level at relapse was compared with the level three months before (considered baseline). For non-relapsed patients, the last two levels during follow-up were compared. For statistical analysis the T-test was used to compare differences in mean values between groups. The sensitivity, specificity, positive and negative predictive values for serum lactate dehydrogenase in detecting relapse compared to confirmatory imaging were calculated.

Results:

At relapse, only 33% patients had increases in serum lactate dehydrogenase above the upper limit of normal. The mean increase was 1.2-fold above the upper limit of normal for relapsed vs. 0.83 for those who did not relapse (p-value = 0.59). The mean increase in serum lactate dehydrogenase, from baseline, was 1.1-fold in non-relapsed vs. 1.3 in relapsed patients (p-value = 0.3). The likelihood ratio of relapse was 4.65 for patients who had 1.5-fold increases in serum ...
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Linfoma não Hodgkin / Seguimentos / Linfoma Difuso de Grandes Células B / L-Lactato Desidrogenase / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Linfoma não Hodgkin / Seguimentos / Linfoma Difuso de Grandes Células B / L-Lactato Desidrogenase / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil