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Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms
Betiati, Dayanne da Silva Borges; Oliveira, Paula Fernanda de; Camargo, Carolina de Quadros; Nunes, Everson Araújo; Trindade, Erasmo Benício Santos de Moraes.
Afiliação
  • Betiati, Dayanne da Silva Borges; Universidade Federal de Santa Catarina. Florianópolis. BR
  • Oliveira, Paula Fernanda de; Universidade Federal de Santa Catarina. Florianópolis. BR
  • Camargo, Carolina de Quadros; Universidade Federal de Santa Catarina. Florianópolis. BR
  • Nunes, Everson Araújo; Universidade Federal de Santa Catarina. Florianópolis. BR
  • Trindade, Erasmo Benício Santos de Moraes; Universidade Federal de Santa Catarina. Florianópolis. BR
Rev. bras. hematol. hemoter ; Rev. bras. hematol. hemoter;35(2): 119-125, 2013. ilus, tab
Article em En | LILACS | ID: lil-676317
Biblioteca responsável: BR408.1
ABSTRACT
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA) metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Leucemia / Biomarcadores Tumorais / Ácidos Docosa-Hexaenoicos / Neoplasias Hematológicas / Ácidos Eicosanoicos / Linfoma Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Leucemia / Biomarcadores Tumorais / Ácidos Docosa-Hexaenoicos / Neoplasias Hematológicas / Ácidos Eicosanoicos / Linfoma Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil