Gabaergic fibers from substantia nigra para reticulata modulate escape bahavior induced by midbrain central gray stimulation
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;22(1): 111-4, 1989. ilus
Article
em En
| LILACS
| ID: lil-67511
Biblioteca responsável:
BR26.1
ABSTRACT
Eletrical stimulation or microinjection of GABA antagonists into the dorsal periaqueductal gray (DPAG) produces escape behavior. In order to determine whether the nigrocollicular gabaergic fibers exert some control over this behavior, rats bearing kainic acid lesion of the substantia nigra pars reticulata were submitted to microinjections of bicuculline or electrical stimulation of the DPAG at the escape threshold. Rats thus treated exhibited a significant decrease in the escape threshold while bicuculline increased the expression of flight behavior. These results suggest an inhibitory control of gabaergic fibers from the substantia nigra pars reticulata on aversive behavior induced by DPAG stimulation
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Comportamento de Esquiva
/
Bicuculina
/
Substância Negra
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1989
Tipo de documento:
Article
/
Project document
País de publicação:
Brasil