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Thyroid peroxidase activity in human nodular goiters
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;22(1): 31-9, 1989. ilus, tab
Article em Pt | LILACS | ID: lil-67470
Biblioteca responsável: BR26.1
RESUMO
1. Thyroid peroxidase (TPO, iodide-oxidation) activity was evaluated in nodular and paranodular tissue samples from 27 patients with nodular goiter (19 "cold" and 8 "hot" nodules), and compared to 11 diffuse toxic goiter and 9 normal thyroid tissue samples. 2. In terms of U/g digitonin solubilized protein, TPO activity was increased in hot nodules (p<0.05), although not as much as in diffuse toxic goiters (p<0.01> 3. The mean TPO activity of tissues paranodular to a cold nodule was not different from that of normal thyroids. 4. Both the highest and the lowest TPO activities were found in cold nodules, but their mean value did not differ from those of their paranodular tissues or normal thyroids. 5. Inter-tissue variability was significantly increased (p<0.01) in cold nodules and in tissues paranoudular to a hot nodule. 6. These data show that heterogeneity both within and among tissues contributes to the wide range of TPO activity detected in nodular goiters
Assuntos
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Glândula Tireoide / Bócio Nodular / Iodeto Peroxidase Limite: Humans Idioma: Pt Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1989 Tipo de documento: Article / Project document País de publicação: Brasil
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Glândula Tireoide / Bócio Nodular / Iodeto Peroxidase Limite: Humans Idioma: Pt Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1989 Tipo de documento: Article / Project document País de publicação: Brasil