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Risk factors for KPC-producing Klebsiella pneumoniae bacteremia
Tuon, Felipe F.; Rocha, Jaime L.; Toledo, Paula; Arend, Lavinia N.; Dias, Camila H.; Leite, Talita M.; Penteado-Filho, Sergio R.; Pilonetto, Marcelo; Zavascki, Alexandre P..
Afiliação
  • Tuon, Felipe F.; Hospital Universitário Evangélico de Curitiba. Division of Infectious and Parasitic Diseases. Curitiba. BR
  • Rocha, Jaime L.; Frischmann Aisengart. Division of Microbiology.
  • Toledo, Paula; Universidade Estadual de Ponta Grossa. Medicine Department. Ponta Grossa. BR
  • Arend, Lavinia N.; Laboratório Central do Estado do Paraná. Curitiba. BR
  • Dias, Camila H.; Hospital Universitário Evangélico de Curitiba. Division of Infectious and Parasitic Diseases. Curitiba. BR
  • Leite, Talita M.; Hospital Universitário Evangélico de Curitiba. Division of Infectious and Parasitic Diseases. Curitiba. BR
  • Penteado-Filho, Sergio R.; Hospital Universitário Evangélico de Curitiba. Division of Infectious and Parasitic Diseases. Curitiba. BR
  • Pilonetto, Marcelo; Laboratório Central do Estado do Paraná. Curitiba. BR
  • Zavascki, Alexandre P.; Hospital de Clínicas de Porto Alegre. Infectious Diseases Service. Porto Alegre. BR
Braz. j. infect. dis ; Braz. j. infect. dis;16(5): 416-419, Sept.-Oct. 2012. ilus, tab
Article em En | LILACS | ID: lil-653427
Biblioteca responsável: BR1.1
ABSTRACT
The molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae (KPC) has been largely investigated, but limited clinical information is available. A case-control study was performed to evaluate the risk factors for KPC bacteremia in hospitalized patients. Cases were patients with KPC bacteremia and controls were patients with non-KPC bacteremia. A total of 85 patients were included, 18 (21.2%) were KPC, and 67 (78.8%) were non-KPC (40 [59.7%] of them were extended-spectrum beta-lactamase producers). All KPC isolates were type 2 producers. These isolates belong to five distinct clones. Multivariate analysis showed that age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02 - 1.11; p = 0.004), presence of mechanical ventilation (OR, 11.1; 95% CI, 1.92 - 63.3; p = 0.007) and fluoroquinolone exposure during hospitalization (OR, 28.9; 95% CI, 1.85 - 454.6; p = 0.02) were independent risk factors for KPC in patients with K. pneumoniae bacteremia. Factors associated with severity of illness, such as age and mechanical ventilation, seem to be the main risks factors for KPC. Fluoroquinolones use might be a risk factor for KPC bacteremia. Further investigations on risk factors for KPC are warranted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Infecções por Klebsiella / Infecção Hospitalar / Bacteriemia / Klebsiella pneumoniae Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2012 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Infecções por Klebsiella / Infecção Hospitalar / Bacteriemia / Klebsiella pneumoniae Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2012 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil