Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
Clinics
; Clinics;67(7): 815-820, July 2012. graf, tab
Article
em En
| LILACS
| ID: lil-645456
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations.METHODS:
Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05.RESULTS:
Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F 3.6 ± 0.2 vs. C 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F 118 ± 3 vs. C 104 ± 4 mmHg) and obesity (F 0.31±0.001 vs. C 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function.CONCLUSION:
The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Condicionamento Físico Animal
/
Disfunção Ventricular Esquerda
/
Síndrome Metabólica
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil