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The effects on mucociliary clearance of prednisone associated with bronchial section
Braga, Karina Andrighetti de Oliveira; Nepomuceno, Natalia Aparecida; Correia, Aristides Tadeu; Jatene, Fabio Biscegli; Pêgo-Fernandes, Paulo Manuel.
Afiliação
  • Braga, Karina Andrighetti de Oliveira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. São Paulo. BR
  • Nepomuceno, Natalia Aparecida; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. São Paulo. BR
  • Correia, Aristides Tadeu; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. São Paulo. BR
  • Jatene, Fabio Biscegli; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. São Paulo. BR
  • Pêgo-Fernandes, Paulo Manuel; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Heart Institute. São Paulo. BR
Clinics ; Clinics;67(6): 647-652, 2012.
Article em En | LILACS | ID: lil-640216
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance.

METHODS:

A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated.

RESULTS:

Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p<0.001). These parameters were normalized 30 days after the surgical procedure. Prednisone improved mucous transportability in the animals undergoing bronchial section and anastomosis at 15 and 30 days (p<0.05).

CONCLUSION:

Bronchial section and anastomosis decrease mucociliary clearance in the early postoperative period. Prednisone therapy improves mucus transportability in animals undergoing bronchial section and anastomosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Brônquios / Prednisona / Depuração Mucociliar / Transplante de Pulmão / Glucocorticoides Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Brônquios / Prednisona / Depuração Mucociliar / Transplante de Pulmão / Glucocorticoides Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil