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Absorption levels and morphological features of fetal organs in wistar rats treated with lead acetate / Niveles de absorción y características morfológicas de los órganos fetales en ratas wistar tratadas con acetato de plomo
Bomfim, Kátia Michelle dos Anjos; Garcia, Carlos Alexandre Borges; Reis, Francisco Prado; Palmeira, José Arnaldo Vasconcelos; Scher, Ricardo; de Lucca Júnior, Waldecy; Aragão, José Adeval; Vasconcelos, Francis Lima; Albuquerque Júnior, Ricardo Luiz Cavalcanti; Feitosa, Vera Lúcia Corrêa.
Afiliação
  • Bomfim, Kátia Michelle dos Anjos; Federal University of Sergipe. Aracaju. BR
  • Garcia, Carlos Alexandre Borges; Federal University of Sergipe. Department of Analytical Chemistry. Aracaju. BR
  • Reis, Francisco Prado; Tiradentes University. School of Medicine. Aracaju. BR
  • Palmeira, José Arnaldo Vasconcelos; Tiradentes University. School of Medicine. Aracaju. BR
  • Scher, Ricardo; Federal University of Sergipe. Department of Morphology. Aracaju. BR
  • de Lucca Júnior, Waldecy; Federal University of Sergipe. Department of Morphology. Aracaju. BR
  • Aragão, José Adeval; Federal University of Sergipe. Department of Morphology. Aracaju. BR
  • Vasconcelos, Francis Lima; Federal University of Sergipe. Aracaju. BR
  • Albuquerque Júnior, Ricardo Luiz Cavalcanti; Research and Technology Institute/UNIT. Aracaju. BR
  • Feitosa, Vera Lúcia Corrêa; Federal University of Sergipe. Department of Morphology. Aracaju. BR
Int. j. morphol ; 30(1): 119-124, mar. 2012. ilus
Article em En | LILACS | ID: lil-638771
Biblioteca responsável: CL1.1
ABSTRACT
Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from control fetuses. Microscopic lesions characterized by vascular sclerosis, cell atrophy or hyperplasia, progressive interstitial fibrosis, inclusion bodies containing lead acetate and glomerular sclerosis were found in the kidneys. The lesions found in the lungs consisted of destructuring of the parenchyma, impregnation with lead acetate, formation of fibrosis, extravasation of vascular fluids, reduction of the alveolar spaces and formation of alveolar edema. These changes were correlated with the level of lead acetate absorption, as determined using atomic spectrophotometry.
RESUMEN
El plomo es un metal pesado utilizado en la industria. El envenenamiento debido a la exposición prolongada por plomo es una enfermedad profesional conocida por muchos años. La toxicidad del plomo es muy expresiva y puede poner en peligro el modelo estructural y funcional de los órganos y sistemas. El objetivo de este estudio fue examinar los pulmones y riñones de fetos de ratas Wistar expuestos al acetato de plomo. En este estudio, 20 fetos de ratas Wistar previamente tratados con acetato de plomo durante la gestación, tuvieron sus órganos disecados, fijados, incluidos en parafina y teñidos con hematoxilina y eosina. Macroscópicamente, los órganos fetales tratados por este metal fueron comparados con los órganos de fetos controles en relación a forma, color y consistencia. Microscópicamente, se encontraron lesiones en el riñón que se caracterizaron por esclerosis vascular, atrofia o hiperplasia de células, fibrosis intersticial progresiva, presencia de cuerpos de inclusión que contenían acetato de plomo y esclerosis glomerular. En el pulmón se observó desorganización del parénquima impregnado con acetato de plomo, formación de fibrosis, líquido intersticial, reducción de los espacios alveolares y edema alveolar. Estos cambios se correlacionaron con el nivel de absorción de acetato de plomo, determinado por espectrometría atómica.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Rim / Chumbo / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int. j. morphol Assunto da revista: ANATOMIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Chile

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Rim / Chumbo / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int. j. morphol Assunto da revista: ANATOMIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Chile