Termodinámica de disolución de triclosán y triclocarbán en algunos solventes orgánicos volátiles / Solution thermodynamics of triclosan and triclocarban in some volatile organic solvents
Vitae (Medellín)
; 19(1): 79-92, ene.-abr. 2012.
Article
em En
| LILACS
| ID: lil-626198
Biblioteca responsável:
CO56.3
ABSTRACT
Thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of the antimicrobial drugs Triclosan (TS) and Triclocarban (TCC) in five volatile organic solvents were calculated from solubility values at temperatures from 293.15 to 313.15 K. TS and Triclocarban solubility was determined in acetone, acetonitrile (AcCN), ethyl acetate (AcOEt), methanol (MetOH), and cyclohexane (CH). The excess of Gibbs energy and the activity coefficients of the solutes were also calculated. The TS solubilities were greater than those of TCC in all the solvents studied. At 298.15 K the solubility diminished for TS in the order, acetone > AcOEt > AcCN > MetOH > CH, while it diminished for TCC in the order, acetone > AcOEt > MetOH > AcCN > CH. On the other hand, thermodynamic quantities relative to the transfer process of these drugs from CH to all other organic solvents, as well as from water to organic solvents for TS were also calculated in order to estimate the hydrogen-bonding contributions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Solubilidade
/
Termodinâmica
Idioma:
En
Revista:
Vitae (Medellín)
Assunto da revista:
FARMACIA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Colômbia