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Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women
Teixeira, Nara Chartuni Pereira; Araújo, Angela Cristina Labanca; Correa, Christine Miranda; Lodi, Claudia Teixeira da Costa; Lima, Maria Inês Miranda; Carvalho, Nara de Oliveira; Castillo, Dora Mendez del; Melo, Victor Hugo.
Afiliação
  • Teixeira, Nara Chartuni Pereira; Department of Health Services. Belo Horizonte. BR
  • Araújo, Angela Cristina Labanca; Department of Health Services. Belo Horizonte. BR
  • Correa, Christine Miranda; Department of Health Services. Belo Horizonte. BR
  • Lodi, Claudia Teixeira da Costa; Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte. BR
  • Lima, Maria Inês Miranda; Department of Health Services. Belo Horizonte. BR
  • Carvalho, Nara de Oliveira; Universidade Federal de Minas Gerais. School of Medicine. Center for Research and Diagnosis. Belo Horizonte. BR
  • Castillo, Dora Mendez del; Universidade Federal de Minas Gerais. School of Medicine. Center for Research and Diagnosis. Belo Horizonte. BR
  • Melo, Victor Hugo; Universidade Federal de Minas Gerais. School of Medicine. Belo Horizonte. BR
Braz. j. infect. dis ; Braz. j. infect. dis;16(2): 164-169, May-Apr. 2012. tab
Article em En | LILACS | ID: lil-622738
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

To evaluate the prevalence and the risk factors for cervical intraepithelial neoplasia (CIN) among HIV-infected women.

METHODS:

Cross-sectional study of 494 HIV-infected women in Brazil, between 1998 and 2008. Gynecologic exam was performed, and samples were collected for cervical cytology and for HPV DNA detection. Cervical biopsy was carried out when indicated. HPV infection, CD4 T-lymphocyte count and HIV viral load were compared with cervical histopathology. Univariate and multivariate statistical analyses were performed to evaluate the statistical association of several risk factors.

RESULTS:

CIN prevalence detected by histopathology was 23.4% (6% of CIN2/3 and 17.4% cases of CIN1). Multivariate analysis confirmed an independent association of CIN with CD4 T-lymphocyte count below 200 cells/mm³ (OR 5.0, 95% CI 2.5-10.1), with a positive detection of HPV DNA (OR 2.0, 95% CI 1.2-3.5), and with age < 34 years old (OR 1.5, 95% CI 1.0-2.4). HIV viral load and antiretroviral use were not independent risk factors for CIN.

CONCLUSIONS:

Severity of immunosupression, presence of HPV infection and younger age are strong predictors of CIN among HIV-infected women.
Assuntos
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por HIV / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por HIV / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil