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The use of interferons in the treatment of pre-invasive cervical neoplasias
Machado, Fernanda A; Michelin, Márcia A; Murta, Eddie F. C.
Afiliação
  • Machado, Fernanda A; Federal University of the Triângulo Mineiro. Oncology Research Institute. Uberaba. BR
  • Michelin, Márcia A; Federal University of the Triângulo Mineiro. Oncology Research Institute. Uberaba. BR
  • Murta, Eddie F. C; Federal University of the Triângulo Mineiro. Oncology Research Institute. Uberaba. BR
ARBS annu. rev. biomed. sci ; ARBS annu. rev. biomed. sci;13(n.esp): 17-22, 2011. ilus
Article em En | LILACS | ID: lil-619904
Biblioteca responsável: BR33.1
ABSTRACT
The evolution of cervical intraepithelial neoplasias(CINs) can lead to the development of cervical carcinomas and is closely tied to infection with human papillomavirus (HPV). Interferon (IFN)’s antitumor effects have a direct bearing on the proliferation or antigen composition of tumor cells, and act on specific tumor cells through immunomodulation. Moreover, some studies have indicated that type 1 IFN can have an antitumor effect by increasing levels of cytotoxic T cells,natural killer (NK) cells and dendritic cells (DCs). Immunotherapy with IFN has recently been used on cervical intraepithelial lesions and invasive cervical cancer with promising results. The objective of this mini-review isto discuss IFNs’ function, importance, and mechanism of action in the treatment of pre-malignant cervicalneoplasias.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Displasia do Colo do Útero / Interferons Limite: Humans Idioma: En Revista: ARBS annu. rev. biomed. sci Assunto da revista: BIOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Displasia do Colo do Útero / Interferons Limite: Humans Idioma: En Revista: ARBS annu. rev. biomed. sci Assunto da revista: BIOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil