TWEAK: ¿una alternativa real en el diagnóstico de nefropatía lúpica? / TWEAK: a real alternative in the diagnosis of lupus nephritis?
Rev. Hosp. Clin. Univ. Chile
; 22(2): 163-170, 2011. ilus, graf
Article
em Es
| LILACS
| ID: lil-613264
Biblioteca responsável:
CL36.1
ABSTRACT
Currently, there is not a marker for early diagnosis of Lupus Nephropathy. TWEAK is a weak Tumor Necrosis Factor whose interaction with the receptor Fn14 in kidney tissue exerts various biological activities including events related to cell proliferation, apoptosis, angiogenesis and inflammation. Because these processes seem to be involved in the pathogenesis of Lupus Nephropathy, it has been proposed that TWEAK could be a potential therapeutic target, but also a predictor of its appearance, and then a possible marker for early diagnosis. The purpose of this article is to discuss the current state of the art in research, of this potential diagnostic tool.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Biomarcadores Tumorais
/
Fatores de Necrose Tumoral
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
Es
Revista:
Rev. Hosp. Clin. Univ. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile