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Osteomalacia hipofosfatémica secundaria a sarcoma de muslo: caso clínico / Hypophosphatemic osteomalacia secondary to a sarcoma: report of one case
Ríos S., Rafael; Goens G., Cristina; Jofré M., Josefina; Martínez C., Virginia; Soto I., Néstor.
Afiliação
  • Ríos S., Rafael; Hospital Clínico San Borja-Arriarán. Unidad de Endocrinología y Diabetes. CL
  • Goens G., Cristina; Universidad de Chile. Departamento de Medicina. CL
  • Jofré M., Josefina; Hospital Militar. Centro PET - Medicina Nuclear. CL
  • Martínez C., Virginia; Universidad de Chile. Facultad de Medicina. Anatomía Patológica. CL
  • Soto I., Néstor; Hospital Clínico San Borja-Arriarán. Unidad de Endocrinología y Diabetes. CL
Rev. chil. endocrinol. diabetes ; 3(1): 15-18, ene. 2010. ilus
Article em Es | LILACS | ID: lil-610314
Biblioteca responsável: CL1.1
ABSTRACT
Tumor induced osteomalacia is uncommon and is characterized by an isolated and not PTH dependent reduction in tubular phosphate reabsorption. This alteration is produced by phosphaturic factors, such as fibroblast growth factor-23 (FGF-23) that are secreted by tumors. We report a 41 years old female presenting with joint pain and progressive loss of muscle strength in the lower limbs. Initial laboratory assessment showed hypophosphatemia, elevated alkaline phosphatases, normal intact parathormone levels, low levels of 25 hydroxy vitamin D and an elevated 24 h phosphaturia. Bone mineral density showed spine and femoral neck osteopenia. A positron emission tomography (PET) revealed a right thigh tumor with lung metastases. Its biopsy disclosed a fibrosarcoma. FGF-23 levels, measured by ELISA were markedly elevated. The patient was discharged with palliative measures.
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Osteomalacia / Sarcoma / Coxa da Perna / Hipofosfatemia Limite: Adult / Female / Humans Idioma: Es Revista: Rev. chil. endocrinol. diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
Coleções: 01-internacional Base de dados: LILACS Assunto principal: Osteomalacia / Sarcoma / Coxa da Perna / Hipofosfatemia Limite: Adult / Female / Humans Idioma: Es Revista: Rev. chil. endocrinol. diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Chile País de publicação: Chile