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Relación entre el polimorfismo -34 Bp de la región promotora del gen CYP17 con el perfil hormonal y metabólico en mujeres con diabetes mellitus tipo 1 / Relationship of -34 Bp polymorphism in the promoter of Cyp17 gene with hormonal and metabolic profile in women with type 1 diabetes mellitus
Pérez B., Francisco; Mohr, Jaqueline; Eyzaguirre C., Francisca; López C., Patricia; Iñiguez V., Germán; Cassorla G., Fernando; Codner, Ethel.
Afiliação
  • Pérez B., Francisco; Universidad de Chile. Facultad de Medicina. Departamento de Nutrición. Laboratorio de Genómica Nutricional. CL
  • Mohr, Jaqueline; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
  • Eyzaguirre C., Francisca; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
  • López C., Patricia; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
  • Iñiguez V., Germán; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
  • Cassorla G., Fernando; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
  • Codner, Ethel; Universidad de Chile. Facultad de Medicina. Instituto de Investigaciones Materno Infantil. CL
Rev. chil. endocrinol. diabetes ; 2(3): 142-146, jul. 2009. tab
Article em Es | LILACS | ID: lil-610291
Biblioteca responsável: CL1.1
ABSTRACT
The P450c17a enzyme has a central role in ovarian hyperandrogenism, which is a characteristic of polycystic ovary syndrome (PCOS). Several studies have suggested a possible role for the CYP17 gene, which codes for the enzyme P450c17a and the -34bp T-C polymorphism in the development of hyperandrogenism. The presence of the cytosine, know as A2 allele, has been associated with hyperandrogenism in patients with PCOS.

Objective:

To evaluate the frequency and association of the -34bp polymorphism in the CYP17 gene and determine its association with hormonal and metabolic characteristics in women with DM1. Patients and

Methods:

The CYP17 polymorphism was studied in 72 DM1 and 71 control women by PCR and RFLP analysis. The CYP17 genetic dosage was compared with the antropometrical characteristics and the serum concentrations of testosterone, androstenedione, DHEAS and 17OH progesterone in women with DM1.

Results:

Genotype A2/A2 was present in 20.8 percent and 7.1 percent of DM1 and controls, respectively (p = 0,034). Allele A2 was present in 40.3 percent and 27.5 percent of DM1 and healthy women, respectively (p = 0,031). No association between CYP17 genotypes and hormonal or metabolic characteristics was observed.

Conclusion:

This study shows that the frequency of the A2/A2 genotype was higher in women with DM1 than in the control group. However, no association between the presence of the polymorphism and circulating steroid levels or BMI was observed.
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Diabetes Mellitus Tipo 1 Limite: Adolescent / Adult / Female / Humans Idioma: Es Revista: Rev. chil. endocrinol. diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2009 Tipo de documento: Article / Project document País de afiliação: Chile País de publicação: Chile
Buscar no Google
Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Diabetes Mellitus Tipo 1 Limite: Adolescent / Adult / Female / Humans Idioma: Es Revista: Rev. chil. endocrinol. diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2009 Tipo de documento: Article / Project document País de afiliação: Chile País de publicação: Chile