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Antiviral activity of Ageratina havanensis and major chemical compounds from the most active fraction
Barrio, Gloria del; Spengler, Iraida; García, Trina; Roque, Annele; Álvarez, Ángel L; Calderón, José S; Parra, Francisco.
Afiliação
  • Barrio, Gloria del; Universidad de la Habana. Facultad de Biología. Departamento de Microbiología y Virología. CU
  • Spengler, Iraida; Universidad de la Habana. Facultad de Química. Centro de Estudios de Productos Naturales. CU
  • García, Trina; Universidad de la Habana. Facultad de Química. Centro de Estudios de Productos Naturales. CU
  • Roque, Annele; Universidad de la Habana. Facultad de Biología. Departamento de Microbiología y Virología. CU
  • Álvarez, Ángel L; Universidad de la Habana. Facultad de Biología. Departamento de Microbiología y Virología. CU
  • Calderón, José S; Universidad Nacional Autónoma de México. Instituto de Química.
  • Parra, Francisco; Universidad de Oviedo. Instituto Universitario de Biotecnología de Asturias. Departamento de Bioquímica y Biología Molecular. ES
Rev. bras. farmacogn ; 21(5): 915-920, Sept.-Oct. 2011. ilus, tab
Article em En | LILACS | ID: lil-600972
Biblioteca responsável: BR1.1
ABSTRACT
The antiviral activity of extracts obtained from Ageratina havanensis (Kunth) R.M.King & H.Rob., Asteraceae, against rabbit vesivirus (RaV) (Caliciviridae) and human herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) (Herpesviridae) were analyzed, and the main metabolites from the most active extract were isolated and characterized. The antiviral properties were investigated by measuring the inhibition of viral-induced cytopathic effect in Vero cells. The strongest inhibitory effects were found for ethyl acetate extract from leaves (SI=5 for RaV and SI=5.4 for HSV-1). The crude ethyl acetate extract was further fractionated by chromatographic methods and the structures of isolated compounds were established through comprehensive spectroscopic analyses, including IR, 2D NMR and MS. Four flavonoids were identified 5,4'-dihydroxy-7-methoxyflavanone (sakuranetin), 3,5,4'-trihydroxy-7-methoxyflavanone (7-methoxyaromadendrin), 4'-O-β-D-glucosyl-5,3'-dihydroxy-7-methoxyflavanone (4'-O-β-D-glucosyl-7-methoxy-eriodictyol) and 4'-O-β-D-glucosyl-5-hydroxy-7-methoxyflavanone (4'-O-β-D-glucosylsakuranetin). This is the first report on antiviral activity for Ageratina havanensis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Rev. bras. farmacogn Assunto da revista: FARMACIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Cuba / México / Espanha País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Rev. bras. farmacogn Assunto da revista: FARMACIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Cuba / México / Espanha País de publicação: Brasil