Ultrastructural changes of the olfactory bulb in manganese-treated mice
Biocell
; Biocell;33(3): 187-197, Dec. 2009. ilus
Article
em En
| LILACS
| ID: lil-595016
Biblioteca responsável:
AR40.1
ABSTRACT
The effect of manganese toxicity on the ultrastructure of the olfactory bulb was evaluated. Male albino mice were injected intraperitoneally with MnCl2 (5 mg/Kg/day) five days per week during nine weeks. The control group received NaCl (0.9%). The olfactory bulbs of five mice from each group were processed for transmission electron microscopy after 2, 4, 6 and 9 weeks of manganese treatment. On week 2, some disorganization of the myelin sheaths was observed. After 4 weeks, degenerated neurons with dilated cisternae of rough endoplasmic reticulum and swollen mitochondria appeared. A certain degree of gliosis with a predominance of astrocytes with swollen mitochondria, disorganization of the endomembrane system, dilation of the perinuclear cisternae and irregularly shaped nuclei with abnormal chromatin distribution were observed after 6 weeks. Some glial cells showed disorganization of the Golgi apparatus. On week 9, an increase in the number of astrocytes, whose mitochondrial cristae were partially or totally erased, and a dilation of the rough endoplasmic reticulum were found. Neurons appear degenerated, with swollen mitochondria and a vacuolated, electron dense cytoplasm. These changes seem to indicate that the olfactory bulb is sensitive to the toxic effects of manganese.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Cloretos
/
Astrócitos
/
Retículo Endoplasmático Rugoso
/
Complexo de Golgi
Limite:
Animals
Idioma:
En
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Argentina