Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats
Clinics
; Clinics;66(6): 1081-1087, 2011. ilus, tab
Article
em En
| LILACS
| ID: lil-594382
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats.INTRODUCTION:
In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases.METHODS:
Twenty-eight adult rats were divided into four groups as follows control group (Group I, no exposure to tobacco or biomass smoke), exposed to tobacco smoke (Group II), exposed to biomass smoke (Group III), and combined exposure to tobacco and biomass smoke (Group IV). After six months the rats in all four groups were sacrificed. Lung tissue samples were examined under light microscopy. The severity of pathological changes was scored.RESULTS:
Group II differed from Group I in all histopathological alterations except intraparenchymal vascular thrombosis. There was no statistically significant difference in histopathological changes between the subjects exposed exclusively to tobacco smoke (Group II) and those with combined exposure to tobacco and biomass smoke (Group IV). The histopathological changes observed in Group IV were found to be more severe than those in subjects exposed exclusively to biomass smoke (Group III).DISCUSSION:
Chronic exposure to tobacco and biomass smoke caused an increase in severity and types of lung injury.CONCLUSION:
Exposure to cigarette smoke caused serious damage to the respiratory system, particularly with concomitant exposure to biomass smoke.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Nicotiana
/
Poluição por Fumaça de Tabaco
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Brasil