HOXB5 expression in oral squamous cell carcinoma
J. appl. oral sci
; J. appl. oral sci;19(2): 125-129, May-Apr. 2011. ilus
Article
em En
| LILACS
| ID: lil-586032
Biblioteca responsável:
BR1.1
ABSTRACT
Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE:
The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL ANDMETHODS:
RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test.RESULTS:
HOXB5 was amplifed in 60 percent non-tumoral epithelium and in 93.3 percent carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade.CONCLUSION:
HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias Bucais
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Carcinoma de Células Escamosas
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Regulação Neoplásica da Expressão Gênica
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Proteínas de Homeodomínio
Limite:
Adult
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Aged
/
Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
J. appl. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
País de publicação:
Brasil