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Estudio genético del síncope vasovagal asociado al polimorfismo Arg389Gly del receptor adrenérgico beta1 / Genetic study of the vasovagal syncope associated to the Arg389Gly polymorphism of the beta1 adrenergic receptor
Hernández-Pacheco, Guadalupe; Serrano, Héctor; Márquez, Manlio F; Hermosillo, Antonio G; Pérez-Vielma, Nadia; Sotomayor, Arturo; Ferreira-Vidal, Alma D; Salas-Silva, Elizabeth; Cárdenas, Manuel.
Afiliação
  • Hernández-Pacheco, Guadalupe; Instituto Nacional de Cardiología Ignacio Chavez. Departamento de Fisiología. MX
  • Serrano, Héctor; Universidad Autónoma Metropolitana Unidad Iztapalapa. División Ciencias Biológicas y de la Salud.
  • Márquez, Manlio F; Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
  • Hermosillo, Antonio G; Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
  • Pérez-Vielma, Nadia; Universidad Autónoma Metropolitana Unidad Iztapalapa. División Ciencias Biológicas y de la Salud.
  • Sotomayor, Arturo; 1Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
  • Ferreira-Vidal, Alma D; 1Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
  • Salas-Silva, Elizabeth; 1Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
  • Cárdenas, Manuel; 1Instituto Nacional de Cardiología Ignacio Chávez. Departamento de Electrocardiología. MX
Arch. cardiol. Méx ; Arch. cardiol. Méx;78(2): 134-138, abr.-jun. 2008.
Article em Es | LILACS | ID: lil-567655
Biblioteca responsável: BR1.1
ABSTRACT
The purpose of this study was to evaluate the correlation between the vasovagal syncope (VVS) and the beta1 adrenergic receptor polymorphism at the 389 position. Seventy individuals with VVS were selected. DNA was extracted from peripheral blood by salting out and subjected to the amplification-restriction test. Genotype identification was made by polyacrylamide gel electrophoresis. A higher frequency in genotype and allele frequencies were found in individuals with positive tilted table test respect individuals with negative test, as well as a marked preference of the GlyGly phenotype in women. Genotype Arg389Gly was the most frequent between individuals with positive response in passive phase with respect to those in the induced phase. When the genotype was analyzed based on the hemodynamic response (VASIS) a gradient is observed in the frequency of Arg389Gly with the highest major frequency in the cardio-inhibitory response followed by the mixed response, and finally the vasodepressor response. These results suggest that the SVV has a genetic component associated with the Arg389Gly polymorphism of the adrenergic receptor. The Gly allele has a high risk association and it is maintained in the population through heterozygosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Receptores Adrenérgicos beta 1 / Síncope Vasovagal Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: Es Revista: Arch. cardiol. Méx Assunto da revista: CARDIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Receptores Adrenérgicos beta 1 / Síncope Vasovagal Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: Es Revista: Arch. cardiol. Méx Assunto da revista: CARDIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: México País de publicação: México