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Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey
Adaleti, Riza; Nakipoglu, Yasar; Ceran, Nurgul; Tasdemir, Cihan; Kaya, Fatma; Tasdemir, Semiha.
Afiliação
  • Adaleti, Riza; Haydarpasa Numune Education and Research Hospital. Clinical Microbiology Laboratory. Istanbul. TR
  • Nakipoglu, Yasar; Istanbul University. Istanbul Faculty of Medicine. Department of Microbiology. Clinical Microbiology. Istanbul. TR
  • Ceran, Nurgul; Haydarpasa Numune Education and Research Hospital. Clinical Microbiology and infectious disease. Istanbul. TR
  • Tasdemir, Cihan; Haydarpasa Numune Education and Research Hospital. Clinical Microbiology Laboratory. Istanbul. TR
  • Kaya, Fatma; Haydarpasa Numune Education and Research Hospital. Clinical Microbiology Laboratory. Istanbul. TR
  • Tasdemir, Semiha; Haydarpasa Numune Education and Research Hospital. Clinical Microbiology Laboratory. Istanbul. TR
Braz. j. infect. dis ; Braz. j. infect. dis;14(1): 11-14, Jan.-Feb. 2010. tab
Article em En | LILACS | ID: lil-545000
Biblioteca responsável: BR1.1
ABSTRACT
The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureus (MSSA) in a total of 516 S. aureus strains to macrolide, lincosamide, streptogramin B (MLS B), ketolid, and linezolid. Disk diffusion method was applied to determine MLS B phenotype and susceptibility to different antibiotic agents. It was found that 54.6 percent of the isolates were resistant to erythromycin (ERSA), 48 percent to clindamycin, 55 percent to azithromycin, 58.7 percent to spiramycin, 34.7 percent to telithromycin, and 0.4 percent to quinupristin-dalfopristin, respectively. No strain resistant to linezolid was found. The prevalence of constitutive (cMLS B), inducible (IMLS B), and macrolides and type B streptogramins (M/MS B) among ERSA isolates (237 MRSA, 45 MSSA) was 69.6 percent, 18.2 percent, and 12.2 percent in MRSA and 28.9 percent, 40 percent, and 31.1 percent in MSSA, respectively. In conclusions, the prevalence of cMLS B was predominant in MRSA; while in MSSA strains, iMLS B and M/MS B phenotype were more higher than cMLS B phenotype resistance. The resistance to quinupristindalfopristin was very low, and linezolid was considered as the most effective antibiotic against all S.aureus strains.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Staphylococcus aureus / Resistência a Meticilina / Macrolídeos / Testes de Sensibilidade a Antimicrobianos por Disco-Difusão / Antibacterianos Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Staphylococcus aureus / Resistência a Meticilina / Macrolídeos / Testes de Sensibilidade a Antimicrobianos por Disco-Difusão / Antibacterianos Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil