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A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin
B. Junior, Walter; Di Chiacchio, Nilton G; Di Chiacchio, Nilton; Romiti, Ricardo; Criado, Paulo R; Velho, Paulo Eduardo N. Ferreira.
Afiliação
  • B. Junior, Walter; São Paulo University. Department of Dermatology. São Paulo. BR
  • Di Chiacchio, Nilton G; Santo Amaro University. BR
  • Di Chiacchio, Nilton; Santo Amaro University. BR
  • Romiti, Ricardo; São Paulo University. Department of Dermatology. São Paulo. BR
  • Criado, Paulo R; São Paulo University. Hospital das Clinicas. Division of Dermatology. São Paulo. BR
  • Velho, Paulo Eduardo N. Ferreira; State University of Campinas. Faculty of Medical Sciences. Division of Dermatology. São Paulo. BR
Braz. j. infect. dis ; Braz. j. infect. dis;13(3): 218-220, June 2009. tab
Article em En | LILACS | ID: lil-538523
Biblioteca responsável: BR1.1
ABSTRACT
A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73 percent with azithromycin and 89 percent with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV positive patients treated with azithromycin (p=0.002) and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tianfenicol / Cancroide / Infecções Oportunistas Relacionadas com a AIDS / Azitromicina / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tianfenicol / Cancroide / Infecções Oportunistas Relacionadas com a AIDS / Azitromicina / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil